Peptide-based vaccine successfully induces protective immunity against canine visceral leishmaniasis

Effective immunotherapy against canine visceral leishmaniasis with the FML-vaccine.

The potential effect of the fucose mannose ligand (FML)-vaccine on immunotherapy of canine visceral leishmaniasis was assayed on five mongrel dogs experimentally infected with Leishmania donovani and on 21 Leishmania chagasi naturally infected dogs when seropositive to FML but completely asymptomatic. The clinical signs of the experimentally infected, symptomatic dogs only disappeared after the...

Leishmaniasis Protective Immunity against Visceral Induces Long Lasting Leishmania donovani Intracellular Replication-Deficient

A gp63 based vaccine candidate against Visceral Leishmaniasis

Visceral leishmaniasis is a macrophage associated disorder which leads to a profound decrease in the natural immunotherapeutic potential of the infected subjects to combat the disease. The major surface glycoprotein gp63 has been found to be a significant vaccine candidate against visceral leishmaniasis. The current study addresses the levels of similarity and identity in the gp63 obtained from...

Protective Immunity and Vaccination Against Cutaneous Leishmaniasis

Although a great deal of knowledge has been gained from studies on the immunobiology of leishmaniasis, there is still no universally acceptable, safe, and effective vaccine against the disease. This strongly suggests that we still do not completely understand the factors that control and/or regulate the development and sustenance of anti-Leishmania immunity, particularly those associated with s...

Immunity to Visceral Leishmaniasis

1 Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, 4 Raja, S. C. Mullick Road, Kolkata-32, West Bengal Kolkata 700032, India 2Faculty of Medicine, Addis Ababa University, P. O. Box 28017-1000, Addis Ababa, Ethiopia 3Departamento de Bioloǵıa Molecular Centro de Bioloǵıa Molecular “Severo Ochoa” C/ Nicolás Cabrera, 1 Universidad Autónoma de Madrid, 28049 Madrid, ...